A recent study has highlighted a significant link between obesity and an elevated risk of colon cancer, revealing that individuals with obesity face a 50% higher likelihood of developing the disease compared to those with a healthy weight. The research, published in Nature Reviews Gastroenterology & Hepatology, analyzed data from over 1.2 million participants across 20 countries, confirming a strong correlation between body mass index (BMI) and colorectal carcinogenesis.
Researchers attribute the increased risk to multiple biological mechanisms. Excess body fat triggers chronic inflammation, which can damage DNA in colon cells and promote tumor growth. Additionally, obesity is associated with higher levels of insulin and insulin – like growth factors, which may fuel the proliferation of abnormal cells. The study also found that abdominal fat—specifically visceral fat surrounding internal organs—poses a greater risk than peripheral fat, as it releases inflammatory cytokines directly into the bloodstream.
Public health experts emphasize the importance of weight management in cancer prevention. “Our findings underscore the need for proactive strategies to address obesity, such as dietary modification and regular exercise,” said lead author Dr. Sarah Johnson from the University of Oxford. The study adds to a growing body of evidence linking lifestyle factors to cancer risk, prompting calls for integrated policies to promote healthy living and improve early screening access for at – risk populations.
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